Bax Antibody
Product Details
- Cat. No.
- 250843
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Bcl-2 blocks cell death following a variety of stimuli and confers a death sparing effect to a certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action. A more recently identified protein, designated as Bax (Bcl-2 associated X protein, Bcl2-L-4, BCL2L4 associated X protein) has exstensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelrates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activity of Bcl-2.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Dog (Canine), Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BAX.
- Isotype: Rabbit Ig
- Gene: Q07812
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)