BCL-10 (4F8) Antibody
Product Details
- Cat. No.
- 252596
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
"Bcl-10 (B-cell CLL/lymphoma 10) is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappa. Bcl-10 interacts with CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. "
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Mouse
- Antigen: Purified recombinant fragment of human BCL-10 expressed in E. coli.
- Clone: 4F8
- Isotype: Mouse IgG1
- Gene: O95999
Handling
- Quantity: 0.1 mg
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- ELISA (ELISA)
- Flow Cytometry (FC)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blotting (WB)