Product & ReviewsAntibodies
BCL-2 (8E12) Antibody
Product Details
- Cat. No.
- 253037
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 regulates cell death by controlling the mitochondrial membrane permeability. Bcl-2 functions in a feedback loop system with caspases by inhibiting caspase activity either by preventing the release of cytochrome c from the mitochondria or by binding to the apoptosis-activating factor (APAF-1).
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Mouse
- Antigen: Synthetic peptide corresponding to residues surrounding BCL-2, conjugated to KLH.
- Clone: 8E12
- Isotype: Mouse IgG1
- Gene: P10415
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)