Product & ReviewsAntibodies
Bcl-2 Antibody
Product Details
- Cat. No.
- 251711
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Apoptosis regulator Bcl-2 (Bcl-2) suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 regulates cell death by controlling mitochondrial membrane permeability. Bcl-2 functions in a feedback loop system with caspases, inhibiting caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). A chromosomal aberration involving Bcl-2 has been found in chronic lymphatic leukemia.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Thyroglobulin-conjugated synthetic peptide encompassing a sequence within the N-term region of human Blcl-2.
- Isotype: Mouse IgG1
- Gene: P10415
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunocytochemistry (ICC)
- Immunohistochemistry (IHC)
- Western Blotting (WB)