Product & ReviewsAntibodies
Beta-Amyloid [1-42] Antibody
Product Details
- Cat. No.
- 250924
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Beta-amyloid production results from cleavage in the extracellular domain of APP by the beta-secretase (BACE1) , which results in the production of the APP C-terminal fragment C99. This fragment is further cleaved by the gamma-secretase at residues 40-42 to produce beta-amyloid 40 and 42 peptides. Beta-amyloid aggregation and neuritic plaque formation are pathologic hallmarks of Alzheimer disease. This fragment is the amino terminus (1-42) of beta-amyloid.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing the sequence (1-42) of human Beta Amyloid.
- Isotype: Rabbit Ig
- Gene: P05067
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)