BIRC5 Antibody
Product Details
- Cat. No.
- 250560
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
BIRC5 (Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor suvivin) is a component of the chromosomal passenger complex (CPC), a key regulator of mitosis that functions at the centromere to ensure correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. With RAN, survivin forms a scaffold for mitotic spindle formation to deliver the RAN effector TPX2 to microtubules. Survivin plsys a role in neoplasia. It inhibits caspase-3 and caspase-7, blocking a default induction of apoptosis in G2/M phase. It is expressed in fetal kidney, liver, lung, brain, adenocarcinomas, lymphomas, renal cell carcinoma cell lines.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Dog (Canine), Human, Pig (Swine)
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BIRC5.
- Isotype: Rabbit Ig
- Gene: O15392
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)