BLK (1E6) Antibody
Product Details
- Cat. No.
- 253094
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
BLK (B lymphoid tyrosine kinase) is a 505-amino acid protein (~56KDa), belongs to the Src non-receptor tyrosine kinases family. Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization and membrane trafficking. Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of human BLK expressed in E. coli.
- Clone: 1E6
- Isotype: Mouse IgG1
- Gene: P51451
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Immunofluorescence (IF)
- Western Blotting (WB)