Product & ReviewsAntibodies

BLM rabbit antibody (pAb)

Product Details

Cat. No.
61055
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
Active Motif

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Description

BLM (Bloom Syndrome protein, RECQ2, RECQL3) is a DNA helicase similar to E. coli RecQ protein that is mutated in patients with Bloom Syndrome, an autosomal recessive disorder characterized by growth deficiency, sun sensitive skin, cancer predisposition and chromosomal instability. The five human RecQ helicases play critical roles in DNA recombination, replication and repair. BLM helps to resolve aberrant chromosome structures generated during DNA replication. It exists in a complex with topoisomerase IIIα, RMI1/BLAP75 and RMI2 and it is thought that BLM complexes are recruited to resolve Holliday junction intermediates. BLM is heavily phosphorylated, especially during mitosis. BLM has a role during meiosis as well, as BLM males are sterile and BLM females have reduced fertility.

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Human
  • Isotype: IgG

Handling

  • Quantity: 100 ul
  • Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Applications

  • Western Blotting (WB)
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