BMI-1 mouse antibody (mAb) (Clone DC9), sample
Product Details
- Cat. No.
- 61090
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
BMI-1 is a member of the Polycomb PRC1 complex that is recruited to transcriptionally repressed genes subsequent to histone H3 lysine 27 methylation in order to maintain repression. In the PRC1 complex, BMI-1 is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2, resulting in the ubiquitylation of histone H2A at lysine 119. BMI-1 acts as an oncogene and cooperates with c-myc in the initiation of lymphoma. High levels of expression of BMI-1 are observed in metastatic melanoma, and BMI-1 has been implicated in several other cancers. BMI-1 is required for hematopoietic stem cell self renewal.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Mouse
- Clone: DC9
- Isotype: IgG1k
Handling
- Quantity: 10 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Immunocytochemistry (ICC)
- Immunofluorescence (IF)
- Western Blotting (WB)