Product & ReviewsAntibodies
BRCA1 Antibody
Product Details
- Cat. No.
- 200160
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Breast cancer type 1 susceptibility protein (BRCA1) plays a central role in DNA repair by facilitating cellular response to DNA repair. BRCA1 is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. BRCA1 is part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. Defects in BRCA1 are a cause of genetic susceptibility to breast and ovarian cancers.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Monkey, Mouse, Pig (Swine), Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human BRCA1.
- Isotype: Rabbit Ig
- Gene: P38398, NP_009225
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)