Product & ReviewsAntibodies
c-erbB-2 Antibody
Product Details
- Cat. No.
- 250600
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
C-erbB-2 (HER2) is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. HER2 has no ligand binding domain on its own and therefore cannot bind growth factors. However, HER2 does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human c-erbB2.
- Isotype: Rabbit Ig
- Gene: P04626
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)