Product & ReviewsAntibodies
caspase-10 Antibody
Product Details
- Cat. No.
- 252225
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Caspase-10 is involved in the activation cascade of caspases responsible for apoptosis execution. Caspase-10 is recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner, and participates in the granzyme B apoptotic pathways. Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Defects in caspase-10 are a cause of familial non-Hodgkin lymphoma (NHL). NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human caspase-10.
- Isotype: Rabbit Ig
- Gene: Q92851
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)