Product & ReviewsAntibodies
Caspase-3 Antibody
Product Details
- Cat. No.
- 251937
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Caspase-3 (CASP-3) is involved in the activation of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Caspase-3 cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase-3 cleaves and activates caspase-6, -7 and -9, and is involved in the cleavage of huntingtin.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Caspase-3.
- Isotype: Rabbit Ig
- Gene: P42574
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)