Product & ReviewsAntibodies
CCND1 (3D8) Antibody
Product Details
- Cat. No.
- 253019
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
CCND1 (Cyclin D1) is a cell-cycle related protein kinase. Complexes with CDK4 and CDK6 serine/threonine protein kinases to impart substrate specificity. Cyclin-D1 is essential for G1/S phase transition. Following DNA damage, Cyclin-D1 is phosphorylated at Thr-286 by MAP kinases, leading to its FBXO31-mediated ubiquitination and subsequent degradation. Chromosomal aberrations of CCND1 lead to various neoplastic and proliferative disorders.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: "Purified recombinant fragment of human CCND1 expressed in E. coli. <br>"
- Clone: 3D8
- Isotype: Mouse IgG1
- Gene: P25322
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)