CCP Antibody
Product Details
- Cat. No.
- 251424
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Citrulline is the deaminated form of arginine. Recently, the detection of citrillunated proteins, specifically keratin, has been of interest in the preliminary diagnosis of rheumatoid arthritis (RA). The epitope of keratin that is recognized by auto-antibodies is cyclic citrulline. Antibodies developed to recognize cyclic citrulline peptide (CCP) have provided earlier RA detection as compared to the historically used rheumatoid factor analysis. This antibody is raised against a peptide derived from human filaggrin cyclized by a disulfide bridge. Filaggrin aggregates intermediate keratin filaments by promoting disulfide bond formation. Filaggrin is modified by citrullination.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Antigen: KLH-conjugated cyclic citrullinated peptide.
- Isotype: Rabbit Ig
- Gene: 372-75-8
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)