CD11a (HI111) Antibody
Product Details
- Cat. No.
- 251000
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our Antibody Directory.
Description
The CD11a (HI111) antibody recognizes the 180-kDa integrin α chain associated with CD18, the 95-kDa integrin β2, which form heterodimer glycoprotein called the lymphocyte function antigen-1 (LFA-1, CD11a/CD18). Leukocytes express four CD11/CD18 integrins which include a common β2 subunit and distinctive α chains. Besides CD11a/CD18, the other three integrins are known as CD11b/CD18, CD11c/CD18 and CD11d/CD18. LFA-1 is expressed on all leukocytes and is responsible for adhesion between leukocytes during immune response and transmigration of leukocytes across endothelium. The ligands for CD11a/CD18 are intercellular adhesion molecules CD54 (ICAM-1), CD102 (ICAM-2) and CD50 (ICAM-3). Patients bearing mutated CD18 genes do not express cell membrane LFA-1, a condition known as leukocyte adhesion deficiency 1 (LAD-1).
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Clone: HI111
- Conjugate: FITC-conjugated Antibody
- Isotype: mouse IgG1
- Gene: P20701
Handling
- Quantity: 2 ml
- Storage: Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Applications
- Flow Cytometry (FC)