Product & ReviewsAntibodies
CD137-ECD, 4B4-1, 0.5 mL, ASR
Product Details
- Cat. No.
- B76262
- Type
- Flow Cytometry Reagents
- Clonality
- Monoclonal
- Host
- Mouse
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Description
CD137, also known as 4-1BB or ILA (for Induced by Lymphocyte Activation) is a 39kDa type I integral membrane protein of the TNF/NGF family. CD137 is expressed on activated T and B cells, NK cells, monocytes and follicular dendritic cells. Differential splicing leads to the release of a 16-kDa soluble from activated T cells. CD137 is involved in monocyte activation by inducing an increase in the production of IL-6, IL-8 and TNF-α, and an inhibition of IL-10 production. In addition, CD137 plays a role in the induction of B lymphocyte apoptosis and the co-stimulation of T-cell proliferation.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: CD137
- Clone: 4B4-1
- Conjugate: ECD
- Isotype: IgG1
Handling
- Quantity: 0.5 mL
Applications
- Flow Cytometry (FC)
