CD152 Antibody
Product Details
- Cat. No.
- 251548
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
CD152 antigen (Cytotoxic T-lymphocyte protein 4, CTLA-4) binds to B7-1 (CD80 antigen) and B7-2 (CD86 antigen), resulting in T-cell activation. Genetic variation in CD152 influences susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. SLE affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Mutations in CD152 have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, thyroid-associated orbitopathy, and other autoimmune diseases.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD152.
- Isotype: Rabbit Ig
- Gene: P16410
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)