CD158i-APC, FES172, 0.5 mL, ASR
Product Details
- Cat. No.
- A60796
- Type
- Flow Cytometry Reagents
- Clonality
- Monoclonal
- Host
- Mouse
The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our Antibody Directory.
Description
The CD158i molecule (also known as p50.3) is a monomeric integral membrane glycoprotein of 50 kDa. This protein belongs to the family of NK receptors for MHC class I molecules. There is another comprehensive nomenclature which refers to this molecule as KIR2DS4; this acronym stands for Killer cell Immunoglobulin (Ig)-like Receptor (KIR), with extracellular part containing 2 Ig domains (2D), and a short (S) cytoplasmic tail. CD158i comprises 2 C-type extracellular Ig domains. The intracytoplasmic portion lacks characteristic ITIM motifs (Immunoreceptor Tyrosine-based Inhibition Motif) and displays a charged residue in the trans-membrane portion. CD158i receptor seems involved in NK cell activation, following HLA-Cw3 supertype recognition. Antibody-induced cross-linking of CD158i (p50.3) results in both early activation events and late effector function.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: CD158i
- Clone: FES172
- Conjugate: APC
- Isotype: IgG2a
Handling
- Quantity: 0.5 mL
Applications
- Flow Cytometry (FC)
