Product & ReviewsAntibodies

CD158i-PE, FES172, 1 mL, ASR

Product Details

Cat. No.
IM3337
Type
Flow Cytometry Reagents
Clonality
Monoclonal
Host
Mouse
Beckman Coulter Life Sciences

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Description

The CD158i molecule (also known as p50.3) is a monomeric integral membrane glycoprotein of 50 kDa. This protein belongs to the family of NK receptors for MHC class I molecules. There is another comprehensive nomenclature which refers to this molecule as KIR2DS4; this acronym stands for Killer cell Immunoglobulin (Ig)-like Receptor (KIR), with extracellular part containing 2 Ig domains (2D), and a short (S) cytoplasmic tail. CD158i comprises 2 C-type extracellular Ig domains. The intracytoplasmic portion lacks characteristic ITIM motifs (Immunoreceptor Tyrosine-based Inhibition Motif) and displays a charged residue in the trans-membrane portion. CD158i receptor seems involved in NK cell activation, following HLA-Cw3 supertype recognition. Antibody-induced cross-linking of CD158i (p50.3) results in both early activation events and late effector function.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Antigen: CD158i
  • Clone: FES172
  • Conjugate: PE
  • Isotype: IgG2a

Handling

  • Quantity: 1 mL

Applications

  • Flow Cytometry (FC)
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