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CD159a (NKG2a) is a 40 kDa (reduced), 75 kDa (unreduced) type II transmembrane protein associated with CD94 to form a disulphide-linked heterodimer. CD159a is a member of the Ca++-dependent (C-type) lectin family. The CD94/NKG2A dimer is an inhibitory NK receptor for MHC Class I, with a broader specificity than Killer cell Immunoglobin (Ig)-like Receptors (KIR). The intracellular portion of CD159a (NKG2A) contains two characteristic ITIM motifs (Immunoreceptor tyrosine based inhibition motif) involved in the transduction of the inhibitory signal. The CD159a (NKG2A) antigen is always co-expressed with CD94. The CD94/NKG2A complex is detectable in sub-populations of NK cells, T cells and thymocytes.
