Product & ReviewsAntibodies
CD18 (10E12) Antibody
Product Details
- Cat. No.
- 252886
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
CD18 is a 95-kDa transmembrane protein, integrin beta-2 subunit. It is associated with the integrin α subunits: CD11a, CD11b, CD11c and CD11d forming four heterodimers named CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1), CD11c/CD18 (p150,95) and CD11d/CD18 (αdβ2). CD18 integrin is expressed exclusively on leukocytes and plays an important role in homotypic and hetorotypic cellular adhesion in immune and inflammatory responses. Patients who have mutated CD18 gene do not express cell membrane CD11/CD18 integrins, a condition known as leucocyte adhesion deficiency (LAD).
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Mouse
- Antigen: Purified recombinant fragment of CD18 expressed in E. coli.
- Clone: 10E12
- Isotype: Mouse IgG2b
- Gene: P05107
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Immunofluorescence (IF)