Product & ReviewsAntibodies
CD184 Antibody
Product Details
- Cat. No.
- 251387
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
C-X-C chemokine receptor type 4 (CXCR-4, CD184) is a receptor for the C-X-C chemokine CXCL12 (SDF-1) that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. CD184 also acts as a receptor for extracellular ubiquitin. CD184 is involved in haemostasis, in cardiac ventricular septum formation and acts as a coreceptor with CD4 for HIV-1 isolates. Defects in CD184 are a cause of WHIM syndrome (warts, hypogammaglobulinemia, infections and myelokathexis).
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD184.
- Isotype: Rabbit Ig
- Gene: P61073
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)