Product & ReviewsAntibodies

CD22-APC, SJ10.1H11, 50 Tests, CE

Product Details

Cat. No.
B96777
Type
Flow Cytometry Reagents
Clonality
Monoclonal
Host
Mouse
Beckman Coulter Life Sciences

The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our  Antibody Directory.

Description

The CD22 antigen (BL-CAM) is a transmembrane glycoprotein of the immunoglobulin superfamily. It may be expressed as two different isoforms: the α form (130 kDa) and the β form (140 kDa). It is a B lineage restricted antigen that occurs in the cytoplasm of early B cell precursors and pre-B cells and on the cell surface of resting and activated B cells. The CD22 antigen is absent from peripheral blood T lymphocytes, granulocytes, monocytes. It is expressed on less than 1% of bone marrow mononuclear cell and 50% of Epstein Barr virus transformed lymphoblastoid B cell lines. CD22 demonstrates heterogeneous expression on resting peripheral blood B lymphocytes. The antigen is lost following activation of B cells with a variety of mitogens. The CD22 molecule regulates signal transduction through the B cell receptor. It is a receptor for certain sialic acid containing glycoproteins.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Antigen: CD22
  • Clone: SJ10.1H11
  • Conjugate: APC
  • Isotype: IgG1

Handling

  • Quantity: 50 tests

Applications

  • Flow Cytometry (FC)
Specificity rating
Sensitivity rating
Quality rating
Write your own review

Product Overview

Links