CD22 (HIB22) Antibody
Product Details
- Cat. No.
- 250955
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
The CD22 (HIB22) antibody recognizes a 130-140 kDa type-I transmembrane glycoprotein that is a B cell restricted antigen. CD22 antigen is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B lymphocytes. CD22 expression is increased after activation and lost at the terminal stage of B cell differentiation. Most B cell leukemias and lymphomas also express CD22. It is not expressed in T cells, monocytes and granulocytes. CD22 is an early marker for B-ALL and hairy-cell leukemia diagnostic. CD22 is an adhesion molecule that amplifies the signal of B cell activation. CD22 ligands are CD45RO antigen on T cells and CD75 antigen on B cells participating in the homotopic interaction of T and B cells.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Clone: HIB22
- Isotype: mouse IgG1
- Gene: P20273, NP_001762
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Flow Cytometry (FC)
- Immunohistochemistry (IHC)