Product & ReviewsAntibodies

CD22 (HIB22) Antibody

Product Details

Cat. No.
251011
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Abbiotec

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Description

The CD22 (HIB22) antibody recognizes a 130-140 kDa type-I transmembrane glycoprotein that is a B cell restricted antigen. CD22 antigen is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B lymphocytes. CD22 expression is increased after activation and lost at the terminal stage of B cell differentiation. Most B cell leukemias and lymphomas also express CD22. It is not expressed in T cells, monocytes and granulocytes. CD22 is an early marker for B-ALL and hairy-cell leukemia diagnostic. CD22 is an adhesion molecule that amplifies the signal of B cell activation. CD22 ligands are CD45RO antigen on T cells and CD75 antigen on B cells participating in the homotopic interaction of T and B cells.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Clone: HIB22
  • Conjugate: FITC-conjugated Antibody
  • Isotype: mouse IgG1
  • Gene: P20273, NP_001762

Handling

  • Quantity: 2 ml
  • Storage: Store at 4°C. Product is guaranteed 6 months from the date of shipment.

Applications

  • Flow Cytometry (FC)
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