CD244-PC5.5, C1.7, 0.5 mL, ASR
Product Details
- Cat. No.
- B21171
- Type
- Flow Cytometry Reagents
- Clonality
- Monoclonal
- Host
- Mouse
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Description
The CD244 antigen, also called 2B4, is a 38 kDa cell surface signal transduction molecule found on almost all human NK cells. It induces a granule independent killing mechanism by NK effector cells. It is also found on γδ TCR T cells and appoximately half of peripheral αβ TCR CD8+ T cells. It is not found on B or naïve CD8+ T cells. Upon activation, most CD8+ T cells become CD244-positive. However, a small but significant minority of CD8+ T cells remain CD244-negative. This subset is associated with lower cytotoxic activity, lower γ-IFN production and higher IL-4 and IL-10 production. CD244 is a high affinity receptor for CD48.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: CD244
- Clone: C1.7
- Conjugate: PC5.5
- Isotype: IgG1
Handling
- Quantity: 0.5 mL
Applications
- Flow Cytometry (FC)
