CD254 Antibody
Product Details
- Cat. No.
- 251263
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Tumor necrosis factor ligand superfamily member 11 (CD254) is a cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. CD254 augments the ability of dendritic cells to stimulate naive T-cell proliferation. CD254 is an important regulator of interactions between T-cells and dendritic cells and plays a role in the regulation of the T-cell-dependent immune response. CD254 also plays a role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Defects in CD254 are the cause of osteopetrosis autosomal recessive type 2 (OPTB2), also known as osteoclast-poor osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Dog (Canine), Human, Mouse, Pig (Swine), Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD254.
- Isotype: Rabbit Ig
- Gene: O14788
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)