CD2AP Antibody
Product Details
- Cat. No.
- 251169
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
CD2-associated protein (CD2AP) is an adapter protein between membrane proteins and the actin cytoskeleton. CD2AP plays a role in receptor clustering and cytoskeletal polarity in the junction between T-cells and antigen-presenting cells. CD2AP anchors the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. CD2AP is also required for cytokinesis. Defects in CD2AP are the cause of susceptibility to focal segmental glomerulosclerosis type 3 (FSGS3), a renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD2AP.
- Isotype: Rabbit Ig
- Gene: Q9Y5K6
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blotting (WB)