CD42b (HIP1) Antibody
Product Details
- Cat. No.
- 251022
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
The CD42b (HIP1) antibody recognizes a heterodimer glycoprotein (GPIbα) that contains an α chain (CD42b, 145 kDa) and a β chain (CD42c, 22 kDa) linked by a disulfide bond forming a noncovalent complex with CD42a (GPIX) and d. CD42b antigen is expressed on platelets and megakaryocytes. The GPIb/IX complex (CD42a-d) serves as a receptor for von Willebrand Factor (vWF) and thrombin, and mediates adhesion of platelets to subendothelium of damaged vascular walls. The absence of the CD42 complex leads to the Bernard-Soulier Syndrome (BSS). The CD42b (HIP1) antibody inhibits the ristocetin-dependent binding of vWF to platelets, ristocetin-induced platelet agglutination, and partially inhibits collagen-induced aggregation.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Clone: HIP1
- Conjugate: FITC-conjugated Antibody
- Isotype: mouse IgG1
- Gene: P07359
Handling
- Quantity: 2 ml
- Storage: Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Applications
- Flow Cytometry (FC)