Product & ReviewsAntibodies

CD42b (HIP1) Antibody

Product Details

Cat. No.
251022
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Abbiotec

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Description

The CD42b (HIP1) antibody recognizes a heterodimer glycoprotein (GPIbα) that contains an α chain (CD42b, 145 kDa) and a β chain (CD42c, 22 kDa) linked by a disulfide bond forming a noncovalent complex with CD42a (GPIX) and d. CD42b antigen is expressed on platelets and megakaryocytes. The GPIb/IX complex (CD42a-d) serves as a receptor for von Willebrand Factor (vWF) and thrombin, and mediates adhesion of platelets to subendothelium of damaged vascular walls. The absence of the CD42 complex leads to the Bernard-Soulier Syndrome (BSS). The CD42b (HIP1) antibody inhibits the ristocetin-dependent binding of vWF to platelets, ristocetin-induced platelet agglutination, and partially inhibits collagen-induced aggregation.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Clone: HIP1
  • Conjugate: FITC-conjugated Antibody
  • Isotype: mouse IgG1
  • Gene: P07359

Handling

  • Quantity: 2 ml
  • Storage: Store at 4°C. Product is guaranteed 6 months from the date of shipment.

Applications

  • Flow Cytometry (FC)
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