CD52 (HI186) Antibody
Product Details
- Cat. No.
- 251083
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
The CD52 (HI186) antibody recognizes a 25-29 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein typically expressed at high levels on thymocytes, lymphocytes, NK cells, monocytes/macrophages. CD52 is expressed at 2% on some granulocytes and epithelial cells of male reproductive tract, and also expressed at variable levels on the majority of lymphoid malignancies, but not on erythrocytes and platelets. A somatic defect in the synthesis of GPI anchors causes a lack of CD52 antigen on cell surface on lymphocytes from patients with paroxysmal nocturnal haemoglobinuria (PNH) . CD52 may be used to diagnose PNH besides CD55 and CD59. All CD52 antibodies are characterized by a strong lytic activity with human complement, irrespective of antibody isotype.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Clone: HI186
- Conjugate: PE-conjugated Antibody
- Isotype: mouse IgG2b
- Gene: P31358
Handling
- Quantity: 2 ml
- Storage: Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Applications
- Flow Cytometry (FC)