CD8 antibody

Rabbit polyclonal to CD8; was first discovered as a cell surface marker in mice and was used to distinguish between CD8+ CTLs and CD4+ Th cells. CD8 exists as both a heterodimer (CD8??) and a homodimer (CD8??) of which the former is expressed on the majority of CTLs. CD8 has been shown to be involved in CTL co-activation by increasing antigen sensitivity; and by stabilizing the TCR/pMHC interaction. In order to carry out these roles; the CD8 co-receptor binds to a distinct invariant region of the pMHCI molecule; compared to the TCR; allowing the potential for tripartite (TCR/pMHC/CD8) complex formation. CD8 is most often described as a T-cell co-receptor because it plays an important role in T-cell signaling; via p56lck; to induce TCR mediated T-cell activation signals. Work in our lab and others has shown that the CD8 co-receptor is also important for CD8+ T-cell development; stabilization of the interface between CD8+ T-cells and target cells; and activation of intestinal epithelial T lymphocytes (iIELs).

• Clonality: Polyclonal
• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clone: NULL
• Conjugate: Unconjugated
• Isotype: IgG
• Gene: 925

• Quantity: 100 ?g; 200 ?g
• Storage: Store at 4°C for up to two weeks. For long term storage; aliquot and store at -20°C; avoid freeze/thaw cycles.
• Buffer: 10 mM PBS; 0.02% sodium azide

• Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))
• Western Blotting (WB)