Product & ReviewsAntibodies
CDK7 Antibody
Product Details
- Cat. No.
- 251214
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Cyclin-dependent kinase 7 (Cdk7) is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. Cdk7 activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. Cdk7 complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Dog (Canine), Horse (Equine), Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human protein CDK7.
- Isotype: Rabbit Ig
- Gene: P50613
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)