Product & ReviewsAntibodies
CDKN1C (3E3) Antibody
Product Details
- Cat. No.
- 253089
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
p57/KIP2 is a potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and to a lesser extent, the mitotic cyclin B-CDC2. p57/KIP2 is a negative regulator of cell proliferation and plays a role in the maintenance of the non-proliferative state throughout life. Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS). BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth and macroglossia.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of human CDKN1C expressed in E. coli.
- Clone: 3E3
- Isotype: Mouse IgG1
- Gene: P49918
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)