CK17 (3B12) Antibody

CK17 (Cytokeratin-17) is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Human
• Antigen: Purified recombinant fragment of CK17 expressed in E. coli.
• Clone: 3B12
• Isotype: Mouse IgG2b
• Gene: Q04695

• Quantity: 0.1 ml
• Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.

• Immunohistochemistry (IHC)
• Western Blotting (WB)