Product & ReviewsAntibodies
CLOCK (8F7) Antibody
Product Details
- Cat. No.
- 252994
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
CLOCK (Circadian locomoter output cycles protein kaput) heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. CLOCK activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. CLOCK has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression. CLOCK acetylates primarily histones H3 and H4.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: "Purified recombinant fragment of human CLOCK expressed in E. coli. <br> <br>"
- Clone: 8F7
- Isotype: Mouse IgG1
- Gene: O15516
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Flow Cytometry (FC)
- Western Blotting (WB)