Connexin-43 (Ser368) Antibody
Product Details
- Cat. No.
- 252529
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Connexin-43 (Gap junction alpha-1 protein, GJA1) forms connexons at cell gap junctions through which materials of low MW diffuse from one cell to a neighboring cell. Connexin-43 has a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Connexons are composed of a hexamer of connexins. Connexin-43 is expressed in the heart and fetal cochlear. Phosphorylation of Ser368 by PKC induces a conformational change of connexin-43 that results in a decrease in gap junction permeability. Defects in connexin-43 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD), a serious condition of cranofacial anomalies, ocular defects and sometimes deafness and cardiac abnormalities.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Chicken, Dog (Canine), Gerbil, Human, Mouse, Zebrafish
- Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser368 of rat connexin 43.
- Isotype: Rabbit Ig
- Modifications: Phosphospecific Antibody
- Gene: P08050
Handling
- Quantity: 0.1 ml
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)