Product & ReviewsAntibodies

CREB (Ser133) Antibody

Product Details

Cat. No.
252530
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
Abbiotec

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Description

As a dimer, CREB-1 (cAMP-responsive element-binding protein 1) binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters, to stimulate transcription. CREB-1 is activated by phosphorylayion on Ser-133 and Ser-142. Transcriptional activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. CREB-1 has been implicated in synchronization of circadian rhythmicity. It interacts with various proteins including TORC/CRTC, CREBBP, ARRB1.

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Bovine, Chicken, Dog (Canine), Human, Mouse, Rat, Sheep (Ovine), Xenopus, Zebrafish
  • Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser133 of rat CREB.
  • Isotype: Rabbit Ig
  • Modifications: Phosphospecific Antibody
  • Gene: P15337

Handling

  • Quantity: 0.1 ml
  • Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Applications

  • ELISA (ELISA)
  • Western Blotting (WB)
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