Product & ReviewsAntibodies
CREB (Ser133) Antibody
Product Details
- Cat. No.
- 252530
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
As a dimer, CREB-1 (cAMP-responsive element-binding protein 1) binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters, to stimulate transcription. CREB-1 is activated by phosphorylayion on Ser-133 and Ser-142. Transcriptional activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. CREB-1 has been implicated in synchronization of circadian rhythmicity. It interacts with various proteins including TORC/CRTC, CREBBP, ARRB1.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Chicken, Dog (Canine), Human, Mouse, Rat, Sheep (Ovine), Xenopus, Zebrafish
- Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser133 of rat CREB.
- Isotype: Rabbit Ig
- Modifications: Phosphospecific Antibody
- Gene: P15337
Handling
- Quantity: 0.1 ml
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)