Product & ReviewsAntibodies

CSE1L Rabbit pAb

Product Details

Cat. No.
A9510
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
ABclonal Technology

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Description

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene.

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Human, Rat

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