Product & ReviewsAntibodies
CSK (5F3) Antibody
Product Details
- Cat. No.
- 253076
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Csk (Carboxy-terminal Src kinase) is a ubiquitously expressed nonreceptor tyrosine kinase. Csk negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK. This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk. It is expressed in lungs and macrophages.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Monkey, Mouse, Rat
- Antigen: Purified recombinant fragment of human CSK expressed in E. coli.
- Clone: 5F3
- Isotype: Mouse IgG1
- Gene: P41240
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Immunofluorescence (IF)
- Western Blotting (WB)