Product & ReviewsAntibodies

CtIP mouse antibody (mAb) (Clone 14-1)

Product Details

Cat. No.
61141
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Active Motif

The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our  Antibody Directory.

Description

CtIP (CTBP interacting protein, RBBP8, RIM, COM1) is a transcriptional regulator and tumor suppressor first identified through its interaction with CTBP (C-Terminal Binding Protein). CtIP binds to the Rb protein and serves as a transcriptional repressor, through recruitment of CtBP and also by interaction with general transcription factors TFIID and TFIIB. CtIP also interacts with Rb-related protein p130 and Ikaros, a master regulator in lymphocyte development. CtIP is phosphorylated upon DNA damage (likely by ATM and/or ATR), interacts with BRCA1 and plays a critical role in facilitating DNA damage repair. Mutations that abolish the interaction between CtIP and BRCA1 result in loss of cell cycle control leading to the development of cancer.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Clone: 14-1
  • Isotype: IgG1

Handling

  • Quantity: 100 ug
  • Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Applications

  • Immunofluorescence (IF)
  • Immunoprecipitation (IP)
  • Western Blotting (WB)
Specificity rating
Sensitivity rating
Quality rating
Write your own review

Product Overview

Links