CtIP mouse antibody (mAb) (Clone 14-1), sample
Product Details
- Cat. No.
- 61142
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
CtIP (CTBP interacting protein, RBBP8, RIM, COM1) is a transcriptional regulator and tumor suppressor first identified through its interaction with CTBP (C-Terminal Binding Protein). CtIP binds to the Rb protein and serves as a transcriptional repressor, through recruitment of CtBP and also by interaction with general transcription factors TFIID and TFIIB. CtIP also interacts with Rb-related protein p130 and Ikaros, a master regulator in lymphocyte development. CtIP is phosphorylated upon DNA damage (likely by ATM and/or ATR), interacts with BRCA1 and plays a critical role in facilitating DNA damage repair. Mutations that abolish the interaction between CtIP and BRCA1 result in loss of cell cycle control leading to the development of cancer.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Clone: 14-1
- Isotype: IgG1
Handling
- Quantity: 10 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Immunofluorescence (IF)
- Immunoprecipitation (IP)
- Western Blotting (WB)