Product & ReviewsAntibodies
Cyclin D1 Antibody
Product Details
- Cat. No.
- 250491
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Cyclin-D1 (BCL-1) complexes with CDK4 and CDK6 serine/threonine protein kinases to impart substrate specificity. Cyclin-D1 is essential for G1/S phase transition. Following DNA damage, Cyclin-D1 is phosphorylated at Thr-286 by MAP kinases, leading to its FBXO31-mediated ubiquitination and subsequent degradation. Chromosomal aberrations of CCND1 lead to various neoplastic and proliferative disorders.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Dog (Canine), Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the central region of rodent Cyclin-D1.
- Isotype: Rabbit Ig
- Gene: P25322
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)