Cyclin D1 Antibody
Product Details
- Cat. No.
- 251740
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
G1/S-specific cyclin-D1 (cyclin D1) is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Defects in cyclin D1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Mouse, Rat
- Antigen: Recombinant human cyclin D1 protein.
- Isotype: Mouse IgG2a
- Gene: P24385
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)