Cyclin D1 Antibody
Product Details
- Cat. No.
- 252030
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
G1/S-specific cyclin-D1 (cyclin D1) is essential for the control of the cell cycle at the G1/S (start) transition. Cyclin D1 interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Cyclin D1 interacts with FBXO4 and CDKN1B. Cyclin D1 is ubiquitinated, primarily as 'Lys-48'-linked polyubiquitination, by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex containing FBXO4 and CRYAB. Defects in cyclin D1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human cyclin D 1.
- Isotype: Rabbit Ig
- Gene: P24385
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)