Cyclin O Antibody
Product Details
- Cat. No.
- 253635
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Cyclin O (CCNO) has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to intrinsec apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Suppression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. This protein was previously called UNG2 after being erroneously identified as a uracil DNA glycolase, but later identified as a cyclin protein family member. This antibody binds to the two isoforms of Cyclin O.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cyclin O.
- Isotype: Rabbit Ig
- Gene: NP_066970
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)