Product & ReviewsAntibodies
CyFlow™ CD105 Alexa Fluor™ 488
Product Details
- Cat. No.
- BM597424
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFβR-2 as a receptor for TGFβ-1 and TGFβ-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonizes the inhibitory effects of TGFβ-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.