Product & ReviewsAntibodies

CyFlow™ CD106 APC

Product Details

Cat. No.
AE544739
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
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Sysmex Europe SE

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Description

CD106 (VCAM-1; vascular cell adhesion molecule-1) is an Ig-like cell surface adhesion molecule binding VLA-4 integrin. VCAM-1 is a potent T cell costimulatory molecule taking part in their positive selection and survival, as well as in adhesion, transendothelial migration and activation of peripheral T cells. VCAM-1 is also involved in endothelial cell-cell contacts. Whereas VCAM-1 normally mediates leukocyte extravasion to sites of tissue inflammation, tumor cells can use overexpressed VCAM-1 to escape T cell immunity. Soluble form of VCAM-1 (sVCAM-1) is an inflammatory marker and can be used also in prognosis of subsequent cariovascular events following acute coronary syndromes.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Antigen: CD106
  • Clone: STA
  • Conjugate: APC
  • Isotype: IgG1

Handling

  • Quantity: 100 tests
  • Storage: Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
  • Buffer: The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.

Applications

  • ELISA (ELISA)
  • Flow Cytometry (FC)
  • Immunohistochemistry (Formalin-Fixed Sections) (IHC (F))
  • Immunoprecipitation (IP)
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