Product & ReviewsAntibodies
CyFlow™ CD11b FITC
Product Details
- Cat. No.
- AE766092
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Rat
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Description
CD11b (integrin αM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with CD18 (integrin β2 subunit); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Human, Mouse, Non-Human Primate, Rabbit (Lapine)
- Antigen: CD11b
- Clone: M1/70
- Conjugate: FITC
- Isotype: IgG2b
Handling
- Quantity: 0.1 mg
- Storage: Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
- Buffer: The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
Applications
- Flow Cytometry (FC)
- Functional Studies (Func)
- Immunohistochemistry (Formalin-Fixed Sections) (IHC (F))
- Immunoprecipitation (IP)