CyFlow™ CD137 Low Endotoxin

CD137 (TNFRSF9, 4-1BB), is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Human, Non-Human Primate
• Antigen: CD137
• Clone: 4B4-1
• Conjugate: Low Endotoxin
• Isotype: IgG1

• Quantity: 0.1 mg
• Storage: Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
• Buffer: The reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

• ELISA (ELISA)
• Flow Cytometry (FC)
• Functional Studies (Func)
• Immunoprecipitation (IP)